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Tyrosine is an amino acid current in proteins that incorporates a hydroxyl moiety, and kinases are enzymes that catalyze phosphorylation (addition of a phosphate group) of assorted substrates within the cell. The group recognized several tyrosine kinase inhibitors that affected circadian rhythms and located evidence suggesting that the Abelson murine leukemia (ABL) and breakpoint cluster region (BCR) protein kinases are involved within the regulation of the mammalian circadian clock.<br>

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