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The imply AUC(0-∞) was 42% better in subjects with impaired hepatic perform than in healthy volunteers. The imply half-life of atazanavir in hepatically impaired topics was 12.1 hours compared to 6.4 hours in healthy volunteers. In wholesome topics, the renal elimination of unchanged atazanavir was roughly 7% of the administered dose. As well as, it is suggested that didanosine be administered on an empty stomach; subsequently, REYATAZ ought to be given (with food) 2 h before or 1 h after didanosine buffered formulations. When coadministered with tenofovir, it's endorsed that REYATAZ 300 mg is given with ritonavir one hundred mg and tenofovir 300 mg (all as a single dailydose with meals). The FDA despatched a notice out this previous week relating to drug-drug interactions between Reyataz (atazanavir) and tenofovir (Viread) and also Viagra and related drugs. The pharmacokinetics of atazanavir in pediatric patients are below investigation. Atazanavir is metabolized and eliminated primarily by the liver.