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The imply AUC(0-∞) was 42% larger in subjects with impaired hepatic perform than in healthy volunteers. The imply half-life of atazanavir in hepatically impaired subjects was 12.1 hours in comparison with 6.Four hours in wholesome volunteers. In wholesome subjects, the renal elimination of unchanged atazanavir was approximately 7% of the administered dose. In addition, it's endorsed that didanosine be administered on an empty stomach; therefore, REYATAZ needs to be given (with meals) 2 h earlier than or 1 h after didanosine buffered formulations. When coadministered with tenofovir, it's endorsed that REYATAZ 300 mg is given with ritonavir a hundred mg and tenofovir 300 mg (all as a single dailydose with meals). The FDA sent a notice out this previous week concerning drug-drug interactions between Reyataz (atazanavir) and tenofovir (Viread) and likewise Viagra and similar medication. The pharmacokinetics of atazanavir in pediatric patients are under investigation. Atazanavir is metabolized and eliminated primarily by the liver.